4 edition of Cell Adhesion Molecules in Cancer and Inflammation (Cell Adhesion and Communication, Vol 1) found in the catalog.
June 1, 1995
Written in English
|The Physical Object|
|Number of Pages||232|
Books Cell Adhesion and Cytoskeletal Molecules in Metastasis (Cancer Metastasis - Biology and. Summary. This book covers the structure and classification of adhesion molecules in relation to signaling pathways and gene expression. It discusses immunohistochemical localization, neutrophil migration, and junctional, functional, and inflammatory adhesion molecules in pathologies such as leukocyte decompression sickness and ischemia reperfusion injury.
Morphogenesis, cell migration and inflammation are the subject of Section III with a focus on the role of integrins in blood cell-endothelial interactions. In Section IV the importance of cell adhesion molecules for cancer and their role as potential target for cancer therapy will be discussed.". For example the inflammation of rheumatoid arthritis occurs when leukocytes enter the joints and release protein-chopping enzymes, oxygen radicals and other toxic factors. (7) Cell-adhesion molecules may play a role in other diseases such as spread of the cancer cells throughout the body. For example the carbohydrates recognized by ELAM-1 are.
Activated leukocyte cell adhesion molecule (ALCAM) or CD is a to KDa transmembrane immunoglobulin which is involved in activation of T-cells, hematopoiesis, neutrophils trans-endothelial migration, angiogenesis, inflammation and tumor propagation and invasiveness through formation of homophilic and heterophilic interactions. 1. Integrins, bind to various receptors 2. Adhesion Molecules, IgG superfamily of Immunoglobulins 3. Cadherins, Ca2+-dependent molecules that mediate cell-to-cell adhesion by homophilic reactions.
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Cell Adhesion Molecules in Cancer and Inflammation (Cell Adhesion and Communication, Vol 1): Medicine & Health Science Books @ hor: Agamemnon A.
Epenetos, Massimo Pignatelii. Cell Adhesion Molecules in Cancer and Inflammation, the first volume in the Cell Adhesion and Communication book series, provides an up-to-date summary of the clinical applications of adhesion molecule research, focusing on the moreRatings: 0.
Molecular Biology of the Cell; Molecular Biology of the Cell: Problems Book; Essential Cell Biology; The Biology of Cancer; Case Studies in Cancer; Janeway's Immunobiology; The Immune System; Case Studies in Immunology; The Molecules of Life; Living in a Microbial World; Please accept our apologies for any inconvenience this may cause.
ISBN: OCLC Number: Description: xvii, pages: illustrations. Contents: Adhesion Molecules in Neoplasia: An Overview - Cell Adhesion Molecules in Mammary Carcinomas - Fibrinolysis and Tissue Degradation in Breast Cancer - Laminin-induced Y Retinoblastoma Cell Differentiation Occurs in the Absence of "Classic" Laminin Adhesion Molecules.
Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (K), or click on a page image below to browse page by by: 4.
Cell Adhesion Molecules in Cancer and Inflammation, the first volume in the Cell Adhesion and Communication book series, provides an up-to-date summary of the clinical applications of adhesion molecule research, focusing on the role played by adhesion molecules (integrins, cadherins, CEA, selectins and CD44) in inflammation and neoplasia.
In addition to participating in tumor invasiveness and metastasis, adhesion molecules regulate or significantly contribute to a variety of functions including signal transduction, cell growth, differentiation, site-specific gene expression, morphogenesis, immunologic function, cell motility, wound healing, and inflammation.
Cell adhesion molecule (CAM), a diverse system of transmembrane glycoproteins Cited by: The overall architecture of a tissue is determined by adhesion mechanisms that involve not only cell-cell interactions but also cell-matrix interactions. In animals, epithelia and most organized groups of cells like muscle are surrounded or underlain by an extracellular matrix (ECM) of collagen fibers, proteoglycans, and multiadhesive matrix : Harvey Lodish, Arnold Berk, S Lawrence Zipursky, Paul Matsudaira, David Baltimore, James Darnell.
Recent data indicate that the inflammatory response is dependent on the presence of both cytokines and adhesion molecules that mediate neutrophil-endothelial cell adhesive interactions. In this article, we review our experience using a lung model of inflammation that Cited by: This book is an elegant review of the molecular mechanisms that control cell adhesion.
It provides a thorough examination of our current understanding of the structure and function of adhesion molecules in development and disease, and it also focuses on the intricate signaling pathways by which adhesion molecules allow cells to respond and adapt to their : Lucia R Languino.
Cell Adhesion Molecules in Health and Disease (Falk Symposium) [W. Reutter, D. Schuppan, R. Tauber, M. Zeitz] on *FREE* shipping on qualifying offers. This book is the proceedings of a Falk Workshop held in Berlin, Germany, on January, which brought together experts in different fields of research to stimulate the transfer of findings from basic research to clinical.
Cell Adhesion Molecules in Cancer and Inflammation 1st Edition. Agamemnon A. Epenetos, Massimo Pignatelii J For personal accounts OR managers of institutional accounts. Username *. Password *. Structure. The VCAM-1 gene contains six or seven immunoglobulin domains, and is expressed on both large and small blood vessels only after the endothelial cells are stimulated by is alternatively spliced into two known RNA transcripts that encode different isoforms in humans.
The gene product is a cell surface sialoglycoprotein, a type I membrane protein that is a member of the Ig Aliases: VCAM1, CD, INCAM, vascular. In cancer, inflammation is manifested by tissue infiltration of inflammatory cells that include macrophages, B and T lymphocytes, natural killer cells, neutrophils, and hages and T cells are the predominant inflammatory cells since they are responsible for the secretion into the microenvironment of large amounts of inflammatory cytokines, proangiogenic factors and reactive Cited by: To orchestrate development and maintain tissue homeostasis, multicellular organisms have evolved a large number of cell adhesion molecules (CAMs).
There are four major classes of CAMs: the immunoglobulin superfamily (IgSF), the cadherins, the integrins and the : Xiajing Tong, Yan Zou. The knowledge that not all cancer cells within tumors have equal tumor growth-supporting potential [the concept of cancer stem cells (CSCs) and tumor cell heterogeneity] is about to revolutionize the way we develop new anticancer drugs and treat cancer patients (13,14).
The focus of this review is on the role of cell adhesion molecules (CAMs Cited by: Cell adhesion molecules play a significant role in cancer progression and metastasis.
Cell-cell interactions of cancer cells with endothelium determine the metastatic spread. In addition, direct tumor cell interactions with platelets, leukocytes, and soluble components significantly contribute to cancer cell adhesion, extravasation, and the establishment of metastatic by: Cell adhesion molecules were first identified through their ability to allow cells to adhere to each other and to the extracellular matrix.
We now know, however, that this group of cell surface receptors not only promotes adhesion but also allows cells to interact and communicate with each other and their environment and, in doing so, regulates a range of cell functions, including Cited by: 8.
Cell adhesion molecules (CAMs) are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix (ECM) in the process called cell essence, cell adhesion molecules help cells stick to each other and to their surroundings.
Cell adhesion is a crucial component in maintaining tissue structure and function. Adhesion molecules & inflammation: Introduction There are many different families of adhesion molecules: vary in molecular structure, and perform different tasks.
Cell-cell adhesion is the result of multiple, different adhesion molecule-ligand binding events Co-operation between different adhesion molecules.
Cell adhesion molecules play a significant role in cancer progression and metastasis. Cell-cell interactions of cancer cells with endothelium determine the metastatic spread.
In addition, direct tumor cell interactions with platelets, leukocytes, and soluble components significantly contribute to cancer cell adhesion, extravasation, and the establishment of metastatic by: A pivotal role for adhesion molecules.
In inflammation, soluble mediators initiate cellular activation of leukocytes and endothelial cells, whereas adhesion molecules allow the interaction of free-flowing leukocytes with the vessel wall and all subsequent adhesive interactions that are Cited by: